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Doug Barrick
Professor, Biophysics


Vincent J. Hilser
Professor, Biology


Katherine Tripp, Ph.D.
Center Manager

Johns Hopkins University
3400 N. Charles Street
Baltimore, MD 21218
(410) 516-3598 office
(410) 516-4118 fax




Meyers lab

X-ray crystallography-based structural elucidation of enzyme-bound intermediates along the 1-deoxy-D-xylulose 5-phosphate synthase reaction coordinate

Barrick Lab

Consensus sequence design as a general strategy to create hyperstable, biologically active proteins

Ha Lab

Extreme mechanical diversity of human telomeric DNA revealed by fluorescence-force spectroscopy

Barrick and Ha Labs

Functional instability allows access to DNA in longer transcription Activator-Like effector (TALE) arrays

Barrick Lab

Extreme stability in de novo-designed repeats arrays is determined by unusually stable short-range interactions

Tovar Lab

Torsional impacts on quaterthiophene segments confined within peptidic nanostructures



Garcia-Moreno Lab

Dielectric properties of a protein probed by reversal of a buried ion pair

Greenberg Lab

Expanded substrate scope of DNA polymerase theta and DNA polymerase beta: Lyase activity on the 5'-overhangs and clustered lesions

Greenberg Lab

Mechanistic insight through irreversible inhibition:DNA polymerase theta uses a common active site for polymerase and lyase activities

Hilser Lab

Assessing allostery in intrinsically disordered protein with ensemble allosteric model

Hilser Lab

Dynamic allostery can drive cold adaptation in enzymes

Lecomte Lab

Lysine as a heme iron ligand: A property common to three truncated hemoglobins from Chlamydomonas reinhardtii

Lecomte Lab

Replacement of the distal histidine reveals a noncanonical heme binding site in a 2-on-2 hemoglobin

Meyers Lab

Oxidative decarboxylation of pyruvate by 1-deoxy-D-xyulose 5-phosphate synthase, a central metabolic enzyme in bacteria




Barrick Lab

Control of transcriptional activity by design of charge patterning in the intrinsically disordered RAM region of the Notch receptor

Barrick Lab

Creating a homeodomain with high stability and DNA binding affinity by sequence averaging

Frueh Lab

Molecular cross-talk between nonribosomal peptide synthetase carrier proteins and unstructured linker regions


Hilser Lab

Structural stability of the coiled-coil domain of tumor susceptibility

Tovar Lab

Nonresonant and local field effects in peptidic nanostructures bearing oligo (p-phenylenevinylene) units

Tovar Lab

Kinetically controlled coassembly of multichromophoric peptide hydrogelators and the impacts on energy transport



Barrick Lab

Broken TALEs: transcription activator-like effectors populate partly folded states

Tovar Lab

Cross-linking approaches to tuning the mechanical properties of peptide π‑electrom hyrdogels



Barrick Lab

Effects of linker length and transient secondary structure elements in the intrinsically disordered Notch RAM region on Notch signaling

Barrick Lab

A naturally occurring repeat protein wth high internal sequence identity defines a new class of TPR-like proteins

Bortvan Lab

A unique HMG-Box domain of mouse maelstrom binds structured RNA but not double stranded DNA

Tovar Lab

Sequence-dependent mechanical, photophysical and electrical properties of pi-conjugated peptide hydrogelators



Lecomte Lab

Characterization of THB1, a Chlamydomonas reinhardtii truncated hemoglobin: linkage to nitrogen metabolism and identification of lysine as the distal heme ligand

Stivers Lab

GTP activator and dNTP substrates of HIV-1 restriction factor and SAMHD1 generate a long-lived activated state


Please let us know when you publish papers that utilized our instrumentation.








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