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Doug Barrick
Professor, Biophysics


Vincent J. Hilser
Professor, Biology


Katherine Tripp, Ph.D.
Center Manager

Johns Hopkins University
3400 N. Charles Street
Baltimore, MD 21218
(410) 516-3598 office
(410) 516-4118 fax

Differential Scanning Calorimetry

  Differential Scanning Calorimetry (DSC) measures enthalpy (ΔH) of unfolding due to heat denaturation.  DSC is also used to determine the change in heat capacity.  DSC can elucidate the factors that contribute to the folding and stability of native biomolecules, including hydrophobic interactions, hydrogen bonding, conformational entropy, and the physical environment. 


DSC sample preparation and instructions

VP-DSC manual

VP-DSC origin data analysis tutorial


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